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Eye health may directly influence a person’s lifespan: Study

The health of your eyes may have a direct correlation on how long you will live, a new study has found.

A team from the US-based Buck Institute for Research on Aging has found a link between diet, circadian rhythms, eye health, and lifespan.

Previous studies have shown in humans that there is an association between eye disorders and poor health.

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“Our study argues that it is more than correlation: Dysfunction of the eye can actually drive problems in other tissues,” said senior author and Buck Institute Professor Pankaj Kapahi, PhD, whose lab has demonstrated for years that fasting and caloric restriction can improve many functions of the body.

“We are now showing that not only does fasting improve eyesight, but the eye actually plays a role in influencing lifespan.”

During this new report, study authors examined the link between eyes health and lifespan among Drosophila — the common fruit fly.

Lead author, Brian Hodge, PhD, said: “The finding that the eye itself, at least in the fruit fly, can directly regulate lifespan was a surprise to us.”

The explanation for this connection, Hodge said, lies in circadian “clocks,” the molecular machinery within every cell of every organism, which have evolved to adapt to daily stresses, such as changes in light and temperature caused by the rising and setting of the sun.

These 24-hour tremblings – circadian rhythms – affect complex animal behaviors, such as predator-prey interactions and sleep/wake cycles, down to fine-tuning the temporal regulation of molecular functions of gene transcription and protein translation.

In 2016 Kapahi’s lab published a study in Cell Metabolism showing that fruit flies on a restricted diet had significant changes in their circadian rhythms in addition to extending lifespan.

“The fruit fly has such a short lifespan, making it a really beautiful model that allows us to screen a lot of things at once,” Hodge says.

Researchers started their new study by examining which genes oscillate with a circadian pattern when flies are on an unrestricted diet. They also compared these insects to another group eating just 10 percent of the protein in the unrestricted diet.

Results show that multiple genes responded to diet changes and also displayed “ups and downs” at different points during the day — just like the body’s internal clock. The team then discovered that the rhythmic genes activated the most by dieting come from the eyes. Specifically, diet restrictions activated photoreceptors, specialized neurons in the retina which respond to changes in light.

This finding led to a series of experiments designed to understand how eye function fit into the story of how dietary restriction can extend lifespan. For example, they set up experiments showing that keeping flies in constant darkness extended their lifespan. “That seemed very strange to us,” said Hodge. “We had thought flies needed the lighting cues to be rhythmic, or circadian.”

They then used bioinformatics to ask: Do the genes in the eye that are also rhythmic and responsive to dietary restriction influence lifespan? The answer was yes they do.

“We always think of the eye as something that serves us, to provide vision. We don’t think of it as something that must be protected to protect the whole organism,” said Kapahi, who is also an associate adjunct professor of urology at UCSF.

Since the eyes are exposed to the outside world, he explained, the immune defenses there are critically active, which can lead to inflammation, which, when present for long periods of time, can cause or worsen a variety of common chronic diseases. Additionally, light in itself can cause photoreceptor degeneration which can cause inflammation.

“Staring at computer and phone screens, and being exposed to light pollution well into the night are conditions very disturbing for circadian clocks,” Kapahi said. “It messes up protection for the eye and that could have consequences beyond just the vision, damaging the rest of the body and the brain.”

There is much to be understood about the role the eye plays in the overall health and lifespan of an organism, including: How does the eye regulate lifespan, and does the same effect apply to other organisms?

The biggest question raised by this work as it might apply to humans is, simply, do photoreceptors in mammals affect longevity? Probably not as much as in fruit flies, said Hodge, noting that the majority of energy in a fruit fly is devoted to the eye.

But since photoreceptors are just specialized neurons, he said, “the stronger link I would argue is the role that circadian function plays in neurons in general, especially with dietary restrictions, and how these can be harnessed to maintain neuronal function throughout aging.”

Once researchers understand how these processes are working, they can begin to target the molecular clock to decelerate aging, said Hodge, adding that it may be that humans could help maintain vision by activating the clocks within our eyes. “It might be through diet, drugs, lifestyle changes… A lot of really interesting research lies ahead,” he said.

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EU Organic Journey Hosts Exclusive B2B Dinner in Dubai, Unveiling European Organic Excellence

The European program “EU Organic Journey”nhosted a distinguished B2B dinner on the evening of the 14th of December 2023 at 19:00, set against the elegant backdrop of MYOCUM Dubai Restaurant (2D St, Al Wasl, Dubai, United Arab Emirates).
Bringing together key players from the Horeca sector, importers, distributors, wholesalers, grocery chains, organic shops, and esteemed food bloggers, the event showcased an array of delectable European organic products, including virgin olive oil, olives, and organic dairy products.
Attendees were treated to a unique opportunity to engage with representatives from the contributing organizations, fostering connections while savoring the exquisite European offerings. The ambiance of MYOCUM Dubai Restaurant provided the perfect setting for meaningful discussions on potential business opportunities. Throughout the evening, participants delved into the heart of the European program  “EU Organic Journey”gaining valuable insights into its initiatives, organic production methods,
and the superior quality of the promoted products. Representatives from the participating organizations were on hand to provide in-depth information, facilitating discussions on potential collaborations and partnerships within the organic industry.
The B2B dinner not only celebrated the richness of European organic products but also served as a platform for networking and knowledge-sharing. Attendees left the event with a deeper understanding of the “EU Organic Journey,” equipped with the information needed to explore new business avenues and enhance their involvement in the organic sector. The EU Financed campaign EU Organic Journey aims to promote and increase the awareness regarding the European organic products from Greece, Romania, and Bulgaria to consumers in UAE, Saudi Arabia and USA with the participation of the organizations Agrodiatrofiki Sympraxi Perifereias Stereas Elladas (ASPSE) from Greece, Bio Carpathia Cooperative from
Romania and National Organic Association (NAO)from Bulgaria.

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Classification: Public New Murabba appointed AtkinsRéalis to masterplan the world’s largest modern downtown in Riyadh, Saudi Arabia

The New Murabba Development Company (NMDC), a fully-owned subsidiary of the Public Investment Fund (PIF), Saudi Arabia,
has appointed AtkinsRéalis (TSX: ATRL), a fully integrated professional services and project management company with offices around the world, to support the design of the New Murabba masterplan, the world’s largest modern downtown in Riyadh, and the Mukaab, an immersive destination that will revolutionize the way in which people experience hospitality, retail and
leisure. A signing ceremony, attended by Sabah Barakat, Acting CEO, New Murabba Development Company, and Campbell Gray, CEO of AtkinsRéalis, Middle East and Africa, was held to mark this milestone and celebrate the ongoing support to deliver Riyadh’s new iconic destination. Sabah Barakat, Acting CEO, New Murabba Development Company, commented: “We are proud
to recognize the important role that AtkinsRéalis has played so far in the translation of the incredible vision of this project into the design of the masterplan and the iconic Mukaab building. We’re also pleased to recognize the ongoing involvement of AtkinsRéalis in this project through a series of recent contract awards relating to the further detailing and definition
of the overall New Murabba masterplan and infrastructure design, as well as the concept design of the iconic Mukaab building.”
“The New Murabba project aligns with Saudi Arabia’s national vision aimed at developing the infrastructure, enabling the private sector, and creating job opportunities for local talent,“ added Campbell Gray, CEO of AtkinsRéalis, Middle East and Africa. “We are proud to work with NMDC on this ambitious project and bring our global engineering excellence and design
expertise, underpinned by cutting-edge technologies and sustainable solutions, to deliver a long-  lasting legacy for the Kingdom and its future generations.” After successfully winning the international architectural and master planning competition for Riyadh’s new icon, AtkinsRéalis will provide its world class advisory, architecture, masterplanning and engineering services to deliver this groundbreaking project, a cornerstone to the visionary reinvention of the Kingdom’s capital city. Contributing to the city’s future development in line with the Saudi Vision 2030, the New Murabba masterplan is inspired by Riyadh’s original balance with nature, and its design is focused on a data-driven approach to sustainability, user convenience, reduction in the need for transport, walkability and people- centric design of its public realm. “Synonymous with designing iconic landmarks in the Middle East, AtkinsRéalis has established a stellar reputation for delivering people-centric destinations combining the region’s cultural identity with modern urban standards,“ said Matthew Tribe, Managing Director, Planning, Design, and Engineering at AtkinsRéalis, Middle East and Africa. “This project win is a testament to our innovative architectural design approach set to redefine downtowns of the future living experience not only in Riyadh but also globally.”

AtkinsRéalis’s competition-winning scheme is inspired by Najdi Architecture, with a focus on creating a futuristic landmark with deep contextual roots that blends Riyadh’s cultural heritage with its future ambitions. The Mukaab, which means cube in Arabic, will be the world’s largest immersive destination providing innovative experiences driven by digital and virtual technology.
The Mukaab’s exterior envelop shrouds an internal skyscraper, which will be one of the largest built structures in the world’s history, standing 400m high, 400m wide, and 400m long. The design of the Mukaab will also include first-of-its-kind hospitality, F&B and retail facilities.

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ASPIRE’s A2RL Debuts Autonomous Racing Car in Abu Dhabi

-Abu Dhabi Autonomous Racing League to hold its first event in April 2024

– A2RL introduces an enhanced version of the 300 km/h Japanese Super Formula SF23 racing car

– Autonomous technology testing commences ahead of inaugural race in April 2024

ASPIRE’s grand challenge, the Abu Dhabi Autonomous Racing League – A2RL, has for the first time revealed its autonomous, highly modified Super Formula SF23 development car. The first glimpse
unfolded at ASPIRE’s offices in Abu Dhabi, near the world-famous Yas Marina Circuit, where the premier event of the season – the Formula 1 (F1) Abu Dhabi Grand Prix 2023 – is currently underway. The same venue will play host to the inaugural A2RL racing event scheduled for next April. Globally acclaimed journalists, representing the world’s most reputable automotive and
racing publications, were also present during the car’s spectacular reveal – further solidifying
the cars status as a trailblazer in the motorsports industry. In April 2024, ten teams spanning North America, Europe, the UAE, and Asia will battle it out to claim a stake in the US$2.25 million purse. The series aims to accelerate autonomous driving development and innovation, pushing the
technology forward for the eventual benefit of road car safety. The new series makes the best use of the forward-thinking and blisteringly quick Super Formula SF23 racing car, developed by motorsport powerhouse Dalarra. All cars will come equipped with an array of sensors and control units as well as a basic level of autonomous performance. The autonomous car unveiled today was fresh off the track, having completed a successful week of testing. Attendees were shown how A2RL’s extensive testing programme has begun to refine the base SF23 platform. This includes validating an array of sensors, controlmodules, and autonomous control software. Once finalized, this base platform will be madeavailable to the ten teams participating in the inaugural A2RL race at Yas Marina Circuit onApril 28, 2024.

His Excellency Faisal Al Bannai, Secretary General of the Advanced Technology
Research Council, ASPIREs parent entity, said, “This is an exciting opportunity to use
extreme sports as the basis for delivering technical advances. A2RL represents an
investment that will contribute to building an autonomous mobility ecosystem in Abu Dhabi,
showcasing safe deployment and encouraging OEM investments for widespread adoption,
ultimately enhancing road safety.”
Stephane Timpano, CEO at ASPIRE, commented: “We are thrilled to debut the A2RL
autonomous racing car to global media. It was an exciting opportunity to discuss our latest
developments and testing while also highlighting the motivation and competitors behind the
competition. A2RL will be the largest autonomous racing league in the world, shifting focus
from drivers to the engineers, scientists, and programmers behind brilliant autonomous
racing systems.”

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